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[108] [109] For example, the enzyme nicotinamidase, which converts nicotinamide to nicotinic acid, is a target for drug design because this enzyme is absent in humans but present in yeast and bacteria

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The key challenges for future research include the selection of patients who may benefit from the treatment, development of optimal therapeutic combinations, and identification of highly sensitive biomarkers for monitoring disease prognosis

Accordingly, the European Society for Clinical Nutrition and Metabolism (ESPEN) [11], the American Association for the Study of Liver Diseases (AASLD) [12], and the Indian National Association for the Study of the Liver (INASL) [13] all recommend a normal protein intake of 1.21.5 g/kg/day in patients with cirrhosis

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